The interplay of conformational states and dynamics in the signaling complexes tune GPCR-mediated functional outcomes. We develop an integrated pharmacology strategy that is based on the combined use of biochemical, biophysical and cell biology methods to illuminate how GPCRs transmit their signal depending on the molecules in their surrounding. The data that will emerge will be crucial for advancing our current understanding of basic mechanisms governing GPCR function. This is of more than academic interest since stabilization of receptor states is also the key to modulating GPCR function in drug design.
Pharmacological Characterization of Selected Ligands on Metabolic Processes: from the cellular target to animal models
Appropriate control of metabolic processes and feeding behavior are essential to achieve energy homeostasis. Our aim is to characterize the pharmacological mechanism by which ghrelin receptor ligands and polyphenols or their metabolites regulate key metabolic processes.
Ghrelin affects glucose tolerance (left) and stimulates food intake (right) in C57BL/6J mice.