Ghrelin Receptor (GHSR) Allostery

These last months we explored how the activity of the Ghrelin Receptor  (GHSR-1a) can be modulated :

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By its ligand Ghrelin

See our paper published in PNAS (2019) on the role of the octanoyl moeity of Ghrelin in its binding to its receptor.

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By lipids

See our paper just published in Nature Comm. (2021) in which we predicted and validated binding sites of PIP2 to the intra-cellular side of the GHSR.

And next ...

What about other partners ?